Anti-ACTA1 antibody (1-100) [S2MR] (STJ11101812) STJ11101812 上海玉博生物科技有限公司

Anti-ACTA1 antibody (1-100) [S2MR] (STJ11101812)

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产品名称：Anti-ACTA1 antibody (1-100) [S2MR] (STJ11101812)
产品型号：STJ11101812
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ACTA1 antibody (1-100) [S2MR] (STJ11101812)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-ACTA1 (1-100) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S2MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ACTA1
Gene ID:	58
Uniprot ID:	ACTS_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Alpha-Actin-1 (ACTA1) (P68133).
Immunogen Sequence:	MCDEDETTALVCDNGSGLVK AGFAGDDAPRAVFPSIVGRP RHQGVMVGMGQKDSYVGDEA QSKRGILTLKYPIEHGIITN WDDMEKIWHHTFYNELRVAP

Post Translational Modifications	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Actin, alpha skeletal muscle, intermediate form: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. Methylated at His-75 by SETD3. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners.
Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Protein Name	Actin - Alpha Skeletal Muscle Alpha-Actin-1 Cleaved Into - Actin - Alpha Skeletal Muscle - Intermediate Form
Database Links	Reactome: R-HSA-390522
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Antibody Names	Anti-Actin - Alpha Skeletal Muscle antibody Anti-Alpha-Actin-1 Cleaved Into - Actin - Alpha Skeletal Muscle - Intermediate Form antibody Anti-ACTA1 antibody Anti-ACTA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ACTA1 antibody (1-100) [S2MR] (STJ11101812)