Anti-ACTA2 antibody (N-Term) [1A4] (STJ180001) STJ180001 上海玉博生物科技有限公司

Anti-ACTA2 antibody (N-Term) [1A4] (STJ180001)

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产品名称：Anti-ACTA2 antibody (N-Term) [1A4] (STJ180001)
产品型号：STJ180001
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ACTA2 antibody (N-Term) [1A4] (STJ180001)

产品描述

Host:	Mouse
Applications:	IHC-P
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-ACTA2 (N-Term) is suitable for use in Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	1A4
Conjugation:	Unconjugated
Isotype:	IgG2a/Kappa
Formulation:	Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification:	Affinity purified
Dilution Range:	1:100
Storage Instruction:	Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.

Gene Symbol:	ACTA2
Gene ID:	59
Uniprot ID:	ACTA_HUMAN
Immunogen Region:	N-Term
Specificity:	Positive control: Smooth muscle or leiomyosarcoma
Immunogen:	N-Terminal decapeptide of alpha smooth muscle isoform of actin; acetylated at the N-terminus

Post Translational Modifications	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Methylated at His-75 by SETD3. Actin, aortic smooth muscle, intermediate form: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners.
Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Protein Name	Actin - Aortic Smooth Muscle Alpha-Actin-2 Cell Growth-Inhibiting Gene 46 Protein Cleaved Into - Actin - Aortic Smooth Muscle - Intermediate Form
Database Links	Reactome: R-HSA-445355 Reactome: R-HSA-9013695
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Antibody Names	Anti-Actin - Aortic Smooth Muscle antibody Anti-Alpha-Actin-2 antibody Anti-Cell Growth-Inhibiting Gene 46 Protein Cleaved Into - Actin - Aortic Smooth Muscle - Intermediate Form antibody Anti-ACTA2 antibody Anti-ACTSA antibody Anti-ACTVS antibody Anti-GIG46 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ACTA2 antibody (N-Term) [1A4] (STJ180001)