Human CD32b (FcgR2b) protein (Recombinant) {Biotin} (STJP000206) STJP000206 上海玉博生物科技有限公司

Human CD32b (FcgR2b) protein (Recombinant) {Biotin} (STJP000206)

简单介绍

Human CD32b (FcgR2b) protein (Recombinant) {Biotin} (STJP000206)

产品描述

Host:	HEK293
Applications:	ELISA/WB
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD32b (FcgR2b)-protein was developed from hek293. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised 0.2 Mu m filtered PBS solution, pH7.2.
Dilution Range:	A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL.
Storage Instruction:	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA

Gene Symbol:	FCGR2B
Gene ID:	2213
Uniprot ID:	FCG2B_HUMAN
Immunogen Region:	ECD
Immunogen:	Optimized DNA sequence encoding Human extracellular domain of human CD32b including a C-terminal 6His tag was expressed in HEK293 cells. CD32b was further labled by Biotin for detection by avidin conjugated secondary probes. NA

Tissue Specificity	Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Post Translational Modifications	Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
Function	Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Protein Name	Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B Igg Fc Receptor Ii-B Cdw32 Fc-Gamma Rii-B Fc-Gamma-Riib Fcrii-B Cd Antigen Cd32
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B protein Igg Fc Receptor Ii-B protein Cdw32 protein Fc-Gamma Rii-B protein Fc-Gamma-Riib protein Fcrii-B protein Cd Antigen Cd32 protein FCGR2B protein CD32 protein FCG2 protein IGFR2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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