Human CD33 (Siglec-3) protein (Recombinant) (STJP000473) STJP000473 上海玉博生物科技有限公司

Human CD33 (Siglec-3) protein (Recombinant) (STJP000473)

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产品名称：Human CD33 (Siglec-3) protein (Recombinant) (STJP000473)
产品型号：STJP000473
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human CD33 (Siglec-3) protein (Recombinant) (STJP000473)

产品描述

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD33 (Siglec-3)-protein was developed from hek293. For use in research applications.

Conjugation:	Unconjugated
Formulation:	Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction:	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA

Gene Symbol:	CD33
Gene ID:	945
Uniprot ID:	CD33_HUMAN
Immunogen Region:	ECD
Immunogen:	Optimized DNA sequence encoding extracellular domain of Human CD33 including a C-terminal His tag was expressed in HEK293 cells. NA

Tissue Specificity	Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Post Translational Modifications	Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition. Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. LCK phosphorylates Tyr-340 efficiently and Tyr-358 to a lesser extent.
Function	Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Protein Name	Myeloid Cell Surface Antigen Cd33 Sialic Acid-Binding Ig-Like Lectin 3 Siglec-3 Gp67 Cd Antigen Cd33
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-6798695
Cellular Localisation	Isoform Cd33m: Cell Membrane Single-Pass Type I Membrane Protein Isoform Cd33m: Peroxisome Cd33m Isoform Does Not Localize To Cell Surfaces But Instead Accumulates In Peroxisomes
Alternative Protein Names	Myeloid Cell Surface Antigen Cd33 protein Sialic Acid-Binding Ig-Like Lectin 3 protein Siglec-3 protein Gp67 protein Cd Antigen Cd33 protein CD33 protein SIGLEC3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human CD33 (Siglec-3) protein (Recombinant) (STJP000473)