Human CD4 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002114) STJP002114-100 上海玉博生物科技有限公司

Human CD4 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002114)

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产品名称：Human CD4 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002114)
产品型号：STJP002114-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human CD4 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002114)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD4-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Immobilized Biotinylated Human CD4 at 0.5 Mu g (100 Mu L/Well) on the plate.Dose response curve for Anti-CD4 Ab, with the EC50 of 21.0 ng/mL determined by ELISA.

Gene Symbol:	CD4
Gene ID:	920
Uniprot ID:	CD4_HUMAN
Immunogen Region:	Lys26-Trp390
Immunogen:	Biotinylated Recombinant Human CD4 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Lys26-Trp390) of Human CD4 fused with His and Avi tag at the C-terminal.

Post Translational Modifications	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Phosphorylated by PKC.phosphorylation at Ser-433 plays an important role for CD4 internalization.
Function	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Down-regulated by HIV-1 Vpu. Acts as a receptor for Human Herpes virus 7/HHV-7.
Protein Name	T-Cell Surface Glycoprotein Cd4 T-Cell Surface Antigen T4/Leu-3 Cd Antigen Cd4
Database Links	Reactome: R-HSA-1462054 Reactome: R-HSA-167590 Reactome: R-HSA-173107 Reactome: R-HSA-180534 Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-389948 Reactome: R-HSA-449836 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Localizes To Lipid Rafts Removed From Plasma Membrane By Hiv-1 Nef Protein That Increases Clathrin-Dependent Endocytosis Of This Antigen To Target It To Lysosomal Degradation Cell Surface Expression Is Also Down-Modulated By Hiv-1 Envelope Polyprotein Gp160 That Interacts With And Sequesters Cd4 In The Endoplasmic Reticulum
Alternative Protein Names	T-Cell Surface Glycoprotein Cd4 protein T-Cell Surface Antigen T4/Leu-3 protein Cd Antigen Cd4 protein CD4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human CD4 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002114)