CDX2 Blocking Peptide for STJ500495 peptide (STJ503840) STJ503840-250 上海玉博生物科技有限公司

CDX2 Blocking Peptide for STJ500495 peptide (STJ503840)

简单介绍

CDX2 Blocking Peptide for STJ500495 peptide (STJ503840)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CDX2 Blocking Peptide for STJ500495 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CDX2
Gene ID:	1045
Uniprot ID:	CDX2_HUMAN
Immunogen Region:	1-50
Specificity:	This blocking peptide is recommended for use in combination with CDX2 antibody, STJ500495
Immunogen:	N-epitope synthetic peptide taken within amino acid region 1-50 on human CDX2 protein.

Tissue Specificity	Detected in small intestine, colon and pancreas.
Post Translational Modifications	Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
Function	Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Peptide Name	Homeobox Protein Cdx-2 Cdx-3 Caudal-Type Homeobox Protein 2
Database Links	Reactome: R-HSA-381771
Cellular Localisation	Nucleus
Alternative Peptide Names	Homeobox Protein Cdx-2 protein Cdx-3 protein Caudal-Type Homeobox Protein 2 protein CDX2 protein CDX3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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