Human SELPLG/CD162 protein (Recombinant) (C-His) (STJP002088) STJP002088 上海玉博生物科技有限公司

Human SELPLG/CD162 protein (Recombinant) (C-His) (STJP002088)

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产品名称：Human SELPLG/CD162 protein (Recombinant) (C-His) (STJP002088)
产品型号：STJP002088
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SELPLG/CD162 protein (Recombinant) (C-His) (STJP002088)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human SELPLG/CD162-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SELPLG
Gene ID:	6404
Uniprot ID:	SELPL_HUMAN
Immunogen Region:	Leu18-Cys320
Immunogen:	Recombinant Human SELPL/CD162 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (CD162 (Leu18-Cys320) ) of human SELPLG (Accession #) fused with a His tag at the C-terminus.

Post Translational Modifications	Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation. Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
Function	A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. (Microbial infection) Acts as a receptor for enterovirus 71.
Protein Name	P-Selectin Glycoprotein Ligand 1 Psgl-1 Selectin P Ligand Cd Antigen Cd162
Database Links	Reactome: R-HSA-202733
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	P-Selectin Glycoprotein Ligand 1 protein Psgl-1 protein Selectin P Ligand protein Cd Antigen Cd162 protein SELPLG protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SELPLG/CD162 protein (Recombinant) (C-His) (STJP002088)