Human Serpin A1/Alpha-1-antitrypsin protein (Recombinant) (C-His) (STJP002614) STJP002614 上海玉博生物科技有限公司

Human Serpin A1/Alpha-1-antitrypsin protein (Recombinant) (C-His) (STJP002614)

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产品名称：Human Serpin A1/Alpha-1-antitrypsin protein (Recombinant) (C-His) (STJP002614)
产品型号：STJP002614
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human Serpin A1/Alpha-1-antitrypsin protein (Recombinant) (C-His) (STJP002614)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Serpin A1/Alpha-1-antitrypsin-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The IC50 value is approximately

Gene Symbol:	SERPINA1
Gene ID:	5265
Uniprot ID:	A1AT_HUMAN
Immunogen Region:	Glu25-Lys418
Immunogen:	Recombinant Human Serpin A1/Alpha-1-antitrypsin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu25-Lys418) of human alpha 1 Antitrypsin (Accession #NP_000286.3) fused with a 6×His tag at the C-

Post Translational Modifications	N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)Man(alpha1-3)Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant. Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418. (Microbial infection) Proteolytically processed by Staphylococcus aureus seryl, cysteinyl, and metallo-proteases.
Function	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Protein Name	Alpha-1-Antitrypsin Alpha-1 Protease Inhibitor Alpha-1-Antiproteinase Serpin A1 Cleaved Into - Short Peptide From Aat Spaat
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-204005 Reactome: R-HSA-381426 Reactome: R-HSA-5694530 Reactome: R-HSA-6798695 Reactome: R-HSA-8957275
Cellular Localisation	Secreted Endoplasmic Reticulum The S And Z Allele Are Not Secreted Effectively And Accumulate Intracellularly In The Endoplasmic Reticulum Short Peptide From Aat: Secreted Extracellular Space Extracellular Matrix
Alternative Protein Names	Alpha-1-Antitrypsin protein Alpha-1 Protease Inhibitor protein Alpha-1-Antiproteinase protein Serpin A1 Cleaved Into - Short Peptide From Aat protein Spaat protein SERPINA1 protein AAT protein PI protein PRO0684 protein PRO2209 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human Serpin A1/Alpha-1-antitrypsin protein (Recombinant) (C-His) (STJP002614)