Anti-ANKH antibody (210-320) (STJ111923) STJ111923 上海玉博生物科技有限公司

Anti-ANKH antibody (210-320) (STJ111923)

简单介绍

Anti-ANKH antibody (210-320) (STJ111923)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ANKH (210-320) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ANKH
Gene ID:	56172
Uniprot ID:	ANKH_HUMAN
Immunogen Region:	210-320
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 210-320 of human ANKH (NP_473368.1).
Immunogen Sequence:	LGYYKNIHDIIPDRSGPELG GDATIRKMLSFWWPLALILA TQRISRPIVNLFVSRDLGGS SAATEAVAILTATYPVGHMP YGWLTEIRAVYPAFDKNNPS NKLVSTSNTVT

Tissue Specificity	Found in osteoblasts from mandibular bone and from iliac bone.not detected in osteoclastic cells.
Function	Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated (Probable).
Protein Name	Mineralization Regulator Ankh Atp Carrier Protein Ankh Progressive Ankylosis Protein Homolog Ank
Database Links	Reactome: R-HSA-5223345
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Mineralization Regulator Ankh antibody Anti-Atp Carrier Protein Ankh antibody Anti-Progressive Ankylosis Protein Homolog antibody Anti-Ank antibody Anti-ANKH antibody Anti-KIAA1581 antibody Anti-UNQ241 antibody Anti-PRO274 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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