Anti-ANKLE2 antibody (350-450) (STJ119707) STJ119707 上海玉博生物科技有限公司

Anti-ANKLE2 antibody (350-450) (STJ119707)

简单介绍

Anti-ANKLE2 antibody (350-450) (STJ119707)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ANKLE2 (350-450) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ANKLE2
Gene ID:	23141
Uniprot ID:	ANKL2_HUMAN
Immunogen Region:	350-450
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human ANKLE2 (NP_055929.1).
Immunogen Sequence:	CRYNVMHVAAKENQASICQL TLDVLENPDFMRLMYPDDDE AMLQKRIRYVVDLYLNTPDK MGYDTPLHFACKFGNADVVN VLSSHHLIVKNSRNKYDKTP E

Function	Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
Protein Name	Ankyrin Repeat And Lem Domain-Containing Protein 2 Lem Domain-Containing Protein 4
Database Links	Reactome: R-HSA-2995383 Reactome: R-HSA-9013404 Reactome: R-HSA-9013408
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Iii Membrane Protein
Alternative Antibody Names	Anti-Ankyrin Repeat And Lem Domain-Containing Protein 2 antibody Anti-Lem Domain-Containing Protein 4 antibody Anti-ANKLE2 antibody Anti-KIAA0692 antibody Anti-LEM4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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