Anti-ANLN antibody (845-1124) (STJ28607) STJ28607 上海玉博生物科技有限公司

Anti-ANLN antibody (845-1124) (STJ28607)

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产品名称：Anti-ANLN antibody (845-1124) (STJ28607)
产品型号：STJ28607
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ANLN antibody (845-1124) (STJ28607)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ANLN (845-1124) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ANLN
Gene ID:	54443
Uniprot ID:	ANLN_HUMAN
Immunogen Region:	845-1124
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 845-1124 of human ANLN (NP_061155.2).
Immunogen Sequence:	ATPLASTSNSLNGDALTFTT TFTLQDVSNDFEINIEVYSL VQKKDPSGLDKKKKTSKSKA ITPKRLLTSITTKSNIHSSV MASPGGLSAVRTSNFALVGS YTLSLSSVGNTKFVLDKVPF LSSLEGHIYLKIKCQVNSSV EERGFLTIFEDVSGFGAWHR RWCVLSGNCISYWTYPDDEK RKNPIGRINLANCTSRQIEP ANREFCARRNTFELITVRPQ REDDRETLVSQCRDTLCVT

Tissue Specificity	Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus. Expression is significantly increased in renal biopsy specimens from idiopathic FSGS. Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Post Translational Modifications	Phosphorylated during mitosis. Ubiquitinated, and this requires FZR1/CDH1.
Function	Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Protein Name	Anillin
Database Links	Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106
Cellular Localisation	Nucleus Cytoplasm Cytoskeleton Cell Cortex Cell Projection Bleb Mainly Found In The Nucleus During Interphase Colocalizes With Cortical F-Actin Upon Nuclear Envelope Breakdown In Mitosis And Subsequently Concentrates In The Area Of The Prospective Contractile Ring In Anaphase This Pattern Persists Until Telophase When The Protein Becomes Concentrated In The Midbody
Alternative Antibody Names	Anti-Anillin antibody Anti-ANLN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ANLN antibody (845-1124) (STJ28607)