Anti-ANO1 antibody (400-500) (STJ112522) STJ112522 上海玉博生物科技有限公司

Anti-ANO1 antibody (400-500) (STJ112522)

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产品名称：Anti-ANO1 antibody (400-500) (STJ112522)
产品型号：STJ112522
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ANO1 antibody (400-500) (STJ112522)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ANO1 (400-500) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:2000 IF/ICC 1:100-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ANO1
Gene ID:	55107
Uniprot ID:	ANO1_HUMAN
Immunogen Region:	400-500
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 400-500 of human ANO1 (NP_060513.5).
Immunogen Sequence:	ASHLFDNPATVFFSVFMALW AATFMEHWKRKQMRLNYRWD LTGFEEEEEAVKDHPRAEYE ARVLEKSLKKESRNKEKRRH IPEESTNKWKQRVKTAMAGV K

Tissue Specificity	Expressed in nasal epithelial cells (at protein level). In the kidney, expressed in the collecting duct (at protein level). Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. Expressed in eccrine sweat glands.
Function	Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression. Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment. Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC. However, was shown in another study not to be required for MUC5AC expression. Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset. In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity. Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae. Acts as a heat sensor in nociceptive neurons. In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs. In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells. Isoform 4: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. Isoform 5: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+).
Protein Name	Anoctamin-1 Discovered On Gastrointestinal Stromal Tumors Protein 1 Oral Cancer Overexpressed Protein 2 Transmembrane Protein 16a Tumor-Amplified And Overexpressed Sequence 2
Database Links	Reactome: R-HSA-2672351 Reactome: R-HSA-9733458
Cellular Localisation	Apical Cell Membrane Multi-Pass Membrane Protein Presynapse In Differentiating Airway Epithelial Cells Predominantly Intracellular At Day 0 But Is Apically Localized By Day 30 Expressed In The Presynapse Of Retinal Neurons
Alternative Antibody Names	Anti-Anoctamin-1 antibody Anti-Discovered On Gastrointestinal Stromal Tumors Protein 1 antibody Anti-Oral Cancer Overexpressed Protein 2 antibody Anti-Transmembrane Protein 16a antibody Anti-Tumor-Amplified And Overexpressed Sequence 2 antibody Anti-ANO1 antibody Anti-DOG1 antibody Anti-ORAOV2 antibody Anti-TAOS2 antibody Anti-TMEM16A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ANO1 antibody (400-500) (STJ112522)