SGK3 Blocking Peptide peptide (STJ504918) STJ504918-250 上海玉博生物科技有限公司

SGK3 Blocking Peptide peptide (STJ504918)

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产品名称：SGK3 Blocking Peptide peptide (STJ504918)
产品型号：STJ504918-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

SGK3 Blocking Peptide peptide (STJ504918)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	SGK3 Blocking Peptide is synthetically produced from the 440-490 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	SGK3
Gene ID:	100533105/23678
Uniprot ID:	SGK3_HUMAN
Immunogen Region:	440-490
Immunogen:	Synthetic peptide taken within amino acid region 440-490 on human Sgk3 protein.

Tissue Specificity	Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors.
Post Translational Modifications	Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
Function	Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
Peptide Name	Serine/Threonine-Protein Kinase Sgk3 Cytokine-Independent Survival Kinase Serum/Glucocorticoid-Regulated Kinase 3 Serum/Glucocorticoid-Regulated Kinase-Like
Database Links	Reactome: R-HSA-2672351
Cellular Localisation	Cytoplasmic Vesicle Early Endosome Recycling Endosome Endosomal Localization Is A Prerequisite For Complete Kinase Activity It Is Essential For Its Colocalization With The Kinase Responsible For Phosphorylating Ser-486 Thus Allowing Pdpk1 Phosphorylation Of Thr-320 Resulting In Complete Activation Of Sgk3 Localized In Vesicle-Like Structures And In The Early Endosome Colocalizes With Slc9a3/Nhe3 In The Recycling Endosomes
Alternative Peptide Names	Serine/Threonine-Protein Kinase Sgk3 protein Cytokine-Independent Survival Kinase protein Serum/Glucocorticoid-Regulated Kinase 3 protein Serum/Glucocorticoid-Regulated Kinase-Like protein SGK3 protein CISK protein SGKL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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SGK3 Blocking Peptide peptide (STJ504918)