Anti-ARSG antibody (376-525) (STJ119309) STJ119309 上海玉博生物科技有限公司

Anti-ARSG antibody (376-525) (STJ119309)

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产品名称：Anti-ARSG antibody (376-525) (STJ119309)
产品型号：STJ119309
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ARSG antibody (376-525) (STJ119309)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ARSG (376-525) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ARSG
Gene ID:	22901
Uniprot ID:	ARSG_HUMAN
Immunogen Region:	376-525
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human ARSG (NP_001254656.1).
Immunogen Sequence:	AQASLPQGRRFDGVDVSEVL FGRSQPGHRVLFHPNSGAAG EFGALQTVRLERYKAFYITG GARACDGSTGPELQHKFPLI FNLEDDTAEAVPLERGGAEY QAVLPEVRKVLADVLQDIAN DNISSADYTQDPSVTPCCNP YQIACRCQAA

Tissue Specificity	Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
Post Translational Modifications	N-glycosylated. N-glycosylated with both high mannose and complex type sugars. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. The 63-kDa precursor undergoes proteolytic processing in two steps, yielding two fragments in the first step (apparent molecular masses of 44 and 18 kDa). In the second step, the 44-kDa fragment is processed further to the 34- and 10-kDa chains. The 10-kDa chain is a cleavage product of the 44-kDa fragment but linked to the 18-kDa chain through a disulfide bridge.
Function	Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
Protein Name	Arylsulfatase G Asg N-Sulfoglucosamine-3-Sulfatase
Database Links	Reactome: R-HSA-1660662 Reactome: R-HSA-1663150
Cellular Localisation	Lysosome The 63-Kda Precursor Protein Localizes To Pre-Lysosomal Compartments And Tightly Associates With Organelle Membranes Most Likely The Endoplasmic Reticulum In Contrast Proteolytically Processed Fragments Of 34- 18- And 10-Kda Are Found In Lysosomal Fractions And Lose Their Membrane Association
Alternative Antibody Names	Anti-Arylsulfatase G antibody Anti-Asg antibody Anti-N-Sulfoglucosamine-3-Sulfatase antibody Anti-ARSG antibody Anti-KIAA1001 antibody Anti-UNQ839 antibody Anti-PRO1777 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ARSG antibody (376-525) (STJ119309)