Human CNR2 (Cannabinoid Receptor 2, Macrophage) Sandwich ELISA Kit (STJE0008011) STJE0008011 上海玉博生物科技有限公司

Human CNR2 (Cannabinoid Receptor 2, Macrophage) Sandwich ELISA Kit (STJE0008011)

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产品名称：Human CNR2 (Cannabinoid Receptor 2, Macrophage) Sandwich ELISA Kit (STJE0008011)
产品型号：STJE0008011
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human CNR2 (Cannabinoid Receptor 2, Macrophage) Sandwich ELISA Kit (STJE0008011)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	24.5pg/mL
Detection Limit:	62.5-4000pg/mL
Short Description:	This CNR2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	CNR2
Gene ID:	1269
Uniprot ID:	CNR2_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Post Translational Modifications	Constitutively phosphorylated on Ser-352.phosphorylation increases cell internalization and desensitizes the receptor.
Function	Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Protein Name	Cannabinoid Receptor 2 Cb-2 Cb2 Hcb2 Cx5
Database Links	Reactome: R-HSA-373076 Reactome: R-HSA-418594
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite Perikaryon Localizes To Apical Dendrite Of Pyramidal Neurons
Alternative ELISA Names	Cannabinoid Receptor 2 ELISA kit Cb-2 ELISA kit Cb2 ELISA kit Hcb2 ELISA kit Cx5 ELISA kit CNR2 ELISA kit CB2A ELISA kit CB2B ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human CNR2 (Cannabinoid Receptor 2, Macrophage) Sandwich ELISA Kit (STJE0008011)