Mouse IL-1RL1/ST2 protein (Recombinant) (C-His) (STJP002769) STJP002769 上海玉博生物科技有限公司

Mouse IL-1RL1/ST2 protein (Recombinant) (C-His) (STJP002769)

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产品名称：Mouse IL-1RL1/ST2 protein (Recombinant) (C-His) (STJP002769)
产品型号：STJP002769
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse IL-1RL1/ST2 protein (Recombinant) (C-His) (STJP002769)

产品描述

Host:	HEK293 cells
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Mouse IL-1RL1/ST2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	Il1rl1
Gene ID:	17082
Uniprot ID:	ILRL1_MOUSE
Immunogen Region:	Ser27-Arg332
Immunogen:	Recombinant Mouse IL-1RL1/ST2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Arg332) of mouse IL-1RL1/ST2 (Accession #NP_001020773.1) fused with a 6×His tag at the C-terminus.

Post Translational Modifications	Phosphorylated by GSK3B at Ser-442.leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response.
Function	Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling.
Protein Name	Interleukin-1 Receptor-Like 1 Interleukin-33 Receptor Alpha Chain Lymphocyte Antigen 84 Protein St2 Protein T1
Database Links	Reactome: R-MMU-1257604 Reactome: -MMU-6811558 Reactome: -MMU-9014843
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Isoform B: Secreted
Alternative Protein Names	Interleukin-1 Receptor-Like 1 protein Interleukin-33 Receptor Alpha Chain protein Lymphocyte Antigen 84 protein Protein St2 protein Protein T1 protein Il1rl1 protein Ly84 protein St2 protein Ste2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse IL-1RL1/ST2 protein (Recombinant) (C-His) (STJP002769)