Mouse IL-23A protein (Recombinant) (C-His) (STJP001972) STJP001972 上海玉博生物科技有限公司

Mouse IL-23A protein (Recombinant) (C-His) (STJP001972)

如果您对该产品感兴趣的话，可以
产品名称：Mouse IL-23A protein (Recombinant) (C-His) (STJP001972)
产品型号：STJP001972
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse IL-23A protein (Recombinant) (C-His) (STJP001972)

产品描述

Host:	HEK293 cells
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Mouse IL-23A-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	Il23a
Gene ID:	83430
Uniprot ID:	IL23A_MOUSE
Immunogen Region:	Ala21-Ala196
Immunogen:	Recombinant Mouse IL-23A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala21-Ala196) of mouse IL-23A (Accession #NP_112542.1) fused with 6×His tag at the C-terminus.

Function	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
Protein Name	Interleukin-23 Subunit Alpha Il-23 Subunit Alpha Il-23-A Interleukin-23 Subunit P19 Il-23p19
Database Links	Reactome: R-MMU-9020933
Cellular Localisation	Secreted Secreted Upon Association With Il12b
Alternative Protein Names	Interleukin-23 Subunit Alpha protein Il-23 Subunit Alpha protein Il-23-A protein Interleukin-23 Subunit P19 protein Il-23p19 protein Il23a protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Mouse IL-23A protein (Recombinant) (C-His) (STJP001972)