Mouse LAG-3/CD223 protein (Recombinant) (C-His) (STJP001320) STJP001320 上海玉博生物科技有限公司

Mouse LAG-3/CD223 protein (Recombinant) (C-His) (STJP001320)

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产品名称：Mouse LAG-3/CD223 protein (Recombinant) (C-His) (STJP001320)
产品型号：STJP001320
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse LAG-3/CD223 protein (Recombinant) (C-His) (STJP001320)

产品描述

Host:	HEK293 cells
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Mouse LAG-3/CD223-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.

Gene Symbol:	Lag3
Gene ID:	16768
Uniprot ID:	LAG3_MOUSE
Immunogen:	Recombinant Mouse LAG-3/CD223 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Leu442) of Mouse LAG3 (Accession #NP_032505.1) fused with an 6×His tag at the C-terminus.

Post Translational Modifications	Lymphocyte activation gene 3 protein: Proteolytically cleaved by ADAM10 and ADAM17 within the connecting peptide region, leading to release of Secreted lymphocyte activation gene 3 protein (sLAG-3). ADAM10 mediates constitutive cleavage, but cleavage increases following T-cell activation, whereas shedding by ADAM17 is induced by TCR signaling in a PRKCQ-dependent manner.
Function	Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II).the precise role of MHC-II-binding is however unclear. Secreted lymphocyte activation gene 3 protein: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
Protein Name	Lymphocyte Activation Gene 3 Protein Lag-3 Activation-Induced Cytidine Deaminase-Linked Autoimmunity Protein Aida Cd Antigen Cd223 Cleaved Into - Secreted Lymphocyte Activation Gene 3 Protein Slag-3
Database Links	Reactome: R-MMU-2132295
Cellular Localisation	Lymphocyte Activation Gene 3 Protein: Cell Membrane Single-Pass Type I Membrane Protein Secreted Lymphocyte Activation Gene 3 Protein: Secreted Produced Following Cleavage Of The Main Chain
Alternative Protein Names	Lymphocyte Activation Gene 3 Protein protein Lag-3 protein Activation-Induced Cytidine Deaminase-Linked Autoimmunity Protein protein Aida protein Cd Antigen Cd223 Cleaved Into - Secreted Lymphocyte Activation Gene 3 Protein protein Slag-3 protein Lag3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse LAG-3/CD223 protein (Recombinant) (C-His) (STJP001320)