SHANK3 Blocking Peptide for STJ502996 peptide (STJ505466) STJ505466-250 上海玉博生物科技有限公司

SHANK3 Blocking Peptide for STJ502996 peptide (STJ505466)

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产品名称：SHANK3 Blocking Peptide for STJ502996 peptide (STJ505466)
产品型号：STJ505466-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

SHANK3 Blocking Peptide for STJ502996 peptide (STJ505466)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	SHANK3 Blocking Peptide for STJ502996 is synthetically produced from the 1600-1650 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Shank3
Gene ID:	58234
Uniprot ID:	SHAN3_MOUSE
Immunogen Region:	1600-1650
Specificity:	This blocking peptide is recommended for use in combination with SHANK3 antibody, STJ502996
Immunogen:	Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3.

Tissue Specificity	In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.
Function	Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
Peptide Name	Sh3 And Multiple Ankyrin Repeat Domains Protein 3 Shank3 Proline-Rich Synapse-Associated Protein 2 Prosap2 Spank-2
Database Links	Reactome: R-MMU-6794361 Reactome: -MMU-8853659
Cellular Localisation	Cytoplasm Synapse Postsynaptic Density Cell Projection Dendritic Spine In Neuronal Cells Extends Into The Region Subjacent To The Postsynaptic Density (Psd)
Alternative Peptide Names	Sh3 And Multiple Ankyrin Repeat Domains Protein 3 protein Shank3 protein Proline-Rich Synapse-Associated Protein 2 protein Prosap2 protein Spank-2 protein Shank3 protein Kiaa1650 protein Prosap2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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SHANK3 Blocking Peptide for STJ502996 peptide (STJ505466)