SIRT5 Blocking Peptide for STJ503039 peptide (STJ504935) STJ504935-250 上海玉博生物科技有限公司

SIRT5 Blocking Peptide for STJ503039 peptide (STJ504935)

简单介绍

SIRT5 Blocking Peptide for STJ503039 peptide (STJ504935)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	SIRT5 Blocking Peptide for STJ503039 is synthetically produced from the 260-310 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Sirt5
Gene ID:	306840
Uniprot ID:	SIR5_RAT
Immunogen Region:	260-310
Specificity:	This blocking peptide is recommended for use in combination with SIRT5 antibody, STJ503039
Immunogen:	Synthetic peptide taken within amino acid region 260-310 on rat Sirtuin 5 protein.

Function	NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity.however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Peptide Name	Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial Regulatory Protein Sir2 Homolog 5 Sir2-Like Protein 5
Database Links	Reactome: R-RNO-2151201
Cellular Localisation	Mitochondrion Cytoplasm Cytosol Nucleus Mainly Mitochondrial Also Present Extramitochondrially With A Fraction Present In The Cytosol And Very Small Amounts Also Detected In The Nucleus
Alternative Peptide Names	Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial protein Regulatory Protein Sir2 Homolog 5 protein Sir2-Like Protein 5 protein Sirt5 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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