Anti-ASAH1 antibody (140-389) (STJ115883) STJ115883 上海玉博生物科技有限公司

Anti-ASAH1 antibody (140-389) (STJ115883)

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产品名称：Anti-ASAH1 antibody (140-389) (STJ115883)
产品型号：STJ115883
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ASAH1 antibody (140-389) (STJ115883)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ASAH1 (140-389) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ASAH1
Gene ID:	427
Uniprot ID:	ASAH1_HUMAN
Immunogen Region:	140-389
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 140-389 of human ASAH1 (NP_001120977.1).
Immunogen Sequence:	IVAEDKKGHLIHGRNMDFGV FLGWNINNDTWVITEQLKPL TVNLDFQRNNKTVFKASSFA GYVGMLTGFKPGLFSLTLNE RFSINGGYLGILEWILGKKD VMWIGFLTRTVLENSTSYEE AKNLLTKTKILAPAYFILGG NQSGEGCVITRDRKESLDVY ELDAKQGRWYVVQTNYDRWK HPFFLDDRRTPAKMCLNRTS QENISFETMYDVLSTKPVLN KLTVYTTLIDVTKGQFETY

Tissue Specificity	Broadly expressed with higher expression in heart.
Post Translational Modifications	N-glycosylated. Proteolytically cleaved into two chains alpha and beta that remain associated via a disulfide bond. Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates. The beta chain may undergo an additional C-terminal processing.
Function	Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a higher catalytic efficiency towards C12-ceramides versus other ceramides. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used. Has also an N-acylethanolamine hydrolase activity. By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes. Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis. By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis. Isoform 2: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity.
Protein Name	Acid Ceramidase Ac Acdase Acid Cdase Acylsphingosine Deacylase N-Acylethanolamine Hydrolase Asah1 N-Acylsphingosine Amidohydrolase Putative 32 Kda Heart Protein Php32 Cleaved Into - Acid Ceramidase Subunit Alpha - Acid Ceramidase Subunit Beta
Database Links	Reactome: R-HSA-1660662 Reactome: R-HSA-6798695
Cellular Localisation	Lysosome Secreted Secretion Is Extremely Low And Localization To Lysosomes Is Mannose-6-Phosphate Receptor-Dependent Isoform 2: Nucleus Cytoplasm A Localization To The Nucleus And The Cytoplasm Has Also Been Reported For Asah1 Most Probably For Isoforms Devoid Of A Signal Peptide
Alternative Antibody Names	Anti-Acid Ceramidase antibody Anti-Ac antibody Anti-Acdase antibody Anti-Acid Cdase antibody Anti-Acylsphingosine Deacylase antibody Anti-N-Acylethanolamine Hydrolase Asah1 antibody Anti-N-Acylsphingosine Amidohydrolase antibody Anti-Putative 32 Kda Heart Protein antibody Anti-Php32 Cleaved Into - Acid Ceramidase Subunit Alpha - Acid Ceramidase Subunit Beta antibody Anti-ASAH1 antibody Anti-ASAH antibody Anti-HSD-33 antibody Anti-HSD33 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ASAH1 antibody (140-389) (STJ115883)