Anti-ASB2 antibody (448-587) (STJ119909) STJ119909 上海玉博生物科技有限公司

Anti-ASB2 antibody (448-587) (STJ119909)

如果您对该产品感兴趣的话，可以
产品名称：Anti-ASB2 antibody (448-587) (STJ119909)
产品型号：STJ119909
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ASB2 antibody (448-587) (STJ119909)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ASB2 (448-587) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ASB2
Gene ID:	51676
Uniprot ID:	ASB2_HUMAN
Immunogen Region:	448-587
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 448-587 of human ASB2 (NP_057234.2).
Immunogen Sequence:	MDLGCDGEPCFSCLYGNGPH PPAPQPSSRFNDAPAADKEP SVVQFCEFVSAPEVSRWAGP IIDVLLDYVGNVQLCSRLKE HIDSFEDWAVIKEKAEPPRP LAHLCRLRVRKAIGKYRIKL LDTLPLPGRLIRYLKYENTQ

Tissue Specificity	Isoform 1: Expressed in muscle cells. Isoform 2: Expressed in hematopoietic cells.
Post Translational Modifications	Isoform 1: Monoubiquitinated. Isoform 2: Not monoubiquitinated. Isoform 2: Phosphorylation at Ser-371 is required for association with FLNA and subsequent FLNA degradation.
Function	Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2. Required during embryonic heart development for complete heart looping. Required for cardiomyocyte differentiation. Isoform 1: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. Also targets DES for proteasomal degradation. Acts as a negative regulator of skeletal muscle mass. Isoform 2: Targets filamins FLNA and FLNB for proteasomal degradation. This leads to enhanced adhesion of hematopoietic cells to fibronectin. Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes. Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix. Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells.
Protein Name	Ankyrin Repeat And Socs Box Protein 2 Asb-2
Database Links	Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Cytoskeleton Stress Fiber Isoform 1: Cytoplasm Myofibril Sarcomere Z Line Localizes To The Z Line In Cardiomyocytes
Alternative Antibody Names	Anti-Ankyrin Repeat And Socs Box Protein 2 antibody Anti-Asb-2 antibody Anti-ASB2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-ASB2 antibody (448-587) (STJ119909)