Anti-ATF6 antibody (600-670) (STJ11103832) STJ11103832 上海玉博生物科技有限公司

Anti-ATF6 antibody (600-670) (STJ11103832)

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产品名称：Anti-ATF6 antibody (600-670) (STJ11103832)
产品型号：STJ11103832
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ATF6 antibody (600-670) (STJ11103832)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha (600-670) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ATF6
Gene ID:	22926
Uniprot ID:	ATF6A_HUMAN
Immunogen Region:	600-670
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 600-670 of human ATF6 (NP_031374.2).
Immunogen Sequence:	INENVINGQDYEVMMQIDCQ VMDTRILHIKSSSVPPYLRD QQRNQTNTFFGSPPAATEAT HVVSTIPESLQ

Tissue Specificity	Ubiquitous.
Post Translational Modifications	During unfolded protein response, a fragment of approximately 50 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR). Ubiquitinated by RNF186 at Lys-152, which is required for pattern recognition receptor-induced unfolded protein response-associated outcomes.
Function	Cyclic AMP-dependent transcription factor ATF-6 alpha: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR. Binds DNA on the 5'-CCACGA-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCACGA-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Protein Name	Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha Camp-Dependent Transcription Factor Atf-6 Alpha Activating Transcription Factor 6 Alpha Atf6-Alpha Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha
Database Links	Reactome: R-HSA-380994 Reactome: R-HSA-381033 Reactome: R-HSA-381183
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Golgi Apparatus Membrane Translocates From The Endoplasmic Reticulum To The Golgi Where It Is Processed Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha: Nucleus Under Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus Thbs4 Promotes Its Nuclear Shuttling
Alternative Antibody Names	Anti-Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha antibody Anti-Camp-Dependent Transcription Factor Atf-6 Alpha antibody Anti-Activating Transcription Factor 6 Alpha antibody Anti-Atf6-Alpha Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha antibody Anti-ATF6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ATF6 antibody (600-670) (STJ11103832)