Anti-ANGPT1 antibody (Internal) (STJ73759) STJ73759-100 上海玉博生物科技有限公司

Anti-ANGPT1 antibody (Internal) (STJ73759)

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产品名称：Anti-ANGPT1 antibody (Internal) (STJ73759)
产品型号：STJ73759-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ANGPT1 antibody (Internal) (STJ73759)

产品描述

Host:	Goat
Applications:	Pep-ELISA/IF/FC
Reactivity:	Human/Mouse/Rat/Dog/Cow/Pig
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-ANGPT1 (Internal) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IF-Strong expression of the protein seen in the plasma membranes of A431 cells. 10µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ANGPT1
Gene ID:	284
Uniprot ID:	ANGP1_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_001137.2; NP_001186788.1
Immunogen Sequence:	TDQYNTNALQR

Function	Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Protein Name	Angiopoietin-1 Ang-1
Database Links	Reactome: R-HSA-210993 Reactome: R-HSA-5673001
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Angiopoietin-1 antibody Anti-Ang-1 antibody Anti-ANGPT1 antibody Anti-KIAA0003 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ANGPT1 antibody (Internal) (STJ73759)