Anti-ANGPTL3 antibody (Internal) (STJ71688) STJ71688-100 上海玉博生物科技有限公司

Anti-ANGPTL3 antibody (Internal) (STJ71688)

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产品名称：Anti-ANGPTL3 antibody (Internal) (STJ71688)
产品型号：STJ71688-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ANGPTL3 antibody (Internal) (STJ71688)

产品描述

Host:	Goat
Applications:	Pep-ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-ANGPTL3 (Internal) is suitable for use in ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	ELISA-antibody detection limit dilution 1:8000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ANGPTL3
Gene ID:	27329
Uniprot ID:	ANGL3_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_055310.1
Immunogen Sequence:	EDQYKQLNQQHSQ

Post Translational Modifications	O-glycosylated at Thr-226 by GALNT2.blocks processing and activation by proprotein convertases. In part proteolytically cleaved by proprotein convertases.proposed to be involved in activation.
Function	Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface.the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol. Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food.the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT. Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity. ANGPTL3(17-221): In vitro inhibits LPL activity.not effective on GPIHBP1-stabilized LPL. Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration. Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling. May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS.
Protein Name	Angiopoietin-Related Protein 3 Angiopoietin-5 Ang-5 Angiopoietin-Like Protein 3 Cleaved Into - Angptl3(17-221 - Angptl3(17-224
Database Links	Reactome: R-HSA-8963889 Reactome: R-HSA-9029558
Cellular Localisation	Secreted Cell Projection Lamellipodium Colocalized With Hspg2 And Activated Itgb3 On Podocytes
Alternative Antibody Names	Anti-Angiopoietin-Related Protein 3 antibody Anti-Angiopoietin-5 antibody Anti-Ang-5 antibody Anti-Angiopoietin-Like Protein 3 Cleaved Into - Angptl3(17-221 - Angptl3(17-224 antibody Anti-ANGPTL3 antibody Anti-ANGPT5 antibody Anti-UNQ153 antibody Anti-PRO179 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ANGPTL3 antibody (Internal) (STJ71688)