Anti-ANGPTL4 antibody (50-100) (STJ500081) STJ500081-100 上海玉博生物科技有限公司

Anti-ANGPTL4 antibody (50-100) (STJ500081)

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产品名称：Anti-ANGPTL4 antibody (50-100) (STJ500081)
产品型号：STJ500081-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ANGPTL4 antibody (50-100) (STJ500081)

产品描述

Host:	Rabbit
Applications:	ELISA/IHC/IP/WB
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ANGPTL4 (50-100) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Angptl4
Gene ID:	57875
Uniprot ID:	ANGL4_MOUSE
Immunogen Region:	50-100
Immunogen:	Synthetic peptide taken within amino acid region 50-100 on mouse Angiopoietin-related protein 4.

Tissue Specificity	Detected in liver and kidney. Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver.
Post Translational Modifications	N-glycosylated. ANGPTL4 N-terminal chain: Forms disulfide-linked dimers and tetramers. Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain.both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.
Function	Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis (Probable). ANGPTL4 N-terminal chain: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
Protein Name	Angiopoietin-Related Protein 4 425o18-1 Angiopoietin-Like Protein 4 Fasting-Induced Adipose Factor Hepatic Fibrinogen/Angiopoietin-Related Protein Hfarp Secreted Protein Bk89 Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain
Database Links	Reactome: R-MMU-8963889 Reactome: -MMU-9762292
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix The Unprocessed Form Interacts With The Extracellular Matrix This May Constitute A Dynamic Reservoir A Regulatory Mechanism Of The Bioavailability Of Angptl4
Alternative Antibody Names	Anti-Angiopoietin-Related Protein 4 antibody Anti-425o18-1 antibody Anti-Angiopoietin-Like Protein 4 antibody Anti-Fasting-Induced Adipose Factor antibody Anti-Hepatic Fibrinogen/Angiopoietin-Related Protein antibody Anti-Hfarp antibody Anti-Secreted Protein Bk89 Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain antibody Anti-Angptl4 antibody Anti-Farp antibody Anti-Fiaf antibody Anti-Ng27 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ANGPTL4 antibody (50-100) (STJ500081)