Human DOCK3 (Dedicator Of Cytokinesis 3) Sandwich ELISA Kit Ready-To-Use (STJE0014864) STJE0014864 上海玉博生物科技有限公司

Human DOCK3 (Dedicator Of Cytokinesis 3) Sandwich ELISA Kit Ready-To-Use (STJE0014864)

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产品名称：Human DOCK3 (Dedicator Of Cytokinesis 3) Sandwich ELISA Kit Ready-To-Use (STJE0014864)
产品型号：STJE0014864
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human DOCK3 (Dedicator Of Cytokinesis 3) Sandwich ELISA Kit Ready-To-Use (STJE0014864)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.053ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This DOCK3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	DOCK3
Gene ID:	1795
Uniprot ID:	DOCK3_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
Post Translational Modifications
Function	Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
Protein Name	Dedicator Of Cytokinesis Protein 3 Modifier Of Cell Adhesion Presenilin-Binding Protein Pbp
Database Links	Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013408 Reactome: R-HSA-9032759 Reactome: R-HSA-983231
Cellular Localisation	Cytoplasm
Alternative ELISA Names	Dedicator Of Cytokinesis Protein 3 ELISA kit Modifier Of Cell Adhesion ELISA kit Presenilin-Binding Protein ELISA kit Pbp ELISA kit DOCK3 ELISA kit KIAA0299 ELISA kit MOCA ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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