Anti-BAD antibody (100-149 aa) (STJ91800) STJ91800 上海玉博生物科技有限公司

Anti-BAD antibody (100-149 aa) (STJ91800)

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产品名称：Anti-BAD antibody (100-149 aa) (STJ91800)
产品型号：STJ91800
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BAD antibody (100-149 aa) (STJ91800)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Bcl2-associated agonist of cell death (100-149 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BAD
Gene ID:	572
Uniprot ID:	BAD_HUMAN
Immunogen Region:	100-149 aa
Specificity:	Bad Polyclonal Antibody detects endogenous levels of Bad protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human BAD at the amino acid range 100-149

Post Translational Modifications	Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis. Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.
Function	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Protein Name	Bcl2-Associated Agonist Of Cell Death Bad Bcl-2-Binding Component 6 Bcl-2-Like Protein 8 Bcl2-L-8 Bcl-Xl/Bcl-2-Associated Death Promoter Bcl2 Antagonist Of Cell Death
Database Links	Reactome: R-HSA-111447 Reactome: R-HSA-111453 Reactome: R-HSA-193648 Reactome: R-HSA-198323 Reactome: R-HSA-5674400
Cellular Localisation	Mitochondrion Outer Membrane Cytoplasm Colocalizes With Hif3a In The Cytoplasm Upon Phosphorylation Locates To The Cytoplasm
Alternative Antibody Names	Anti-Bcl2-Associated Agonist Of Cell Death antibody Anti-Bad antibody Anti-Bcl-2-Binding Component 6 antibody Anti-Bcl-2-Like Protein 8 antibody Anti-Bcl2-L-8 antibody Anti-Bcl-Xl/Bcl-2-Associated Death Promoter antibody Anti-Bcl2 Antagonist Of Cell Death antibody Anti-BAD antibody Anti-BBC6 antibody Anti-BCL2L8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BAD antibody (100-149 aa) (STJ91800)