Anti-APOBEC3G antibody (244-257) (STJ115559) STJ115559 上海玉博生物科技有限公司

Anti-APOBEC3G antibody (244-257) (STJ115559)

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产品名称：Anti-APOBEC3G antibody (244-257) (STJ115559)
产品型号：STJ115559
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-APOBEC3G antibody (244-257) (STJ115559)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-APOBEC3G (244-257) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	APOBEC3G
Gene ID:	60489
Uniprot ID:	ABC3G_HUMAN
Immunogen Region:	244-257
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 244-257 of human APOBEC3G (NP_068594.1).
Immunogen Sequence:	NQAPHKHGFLEGRH

Tissue Specificity	Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines.no expression detected in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral blood-derived resting CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is converted to a HMM complex when resting CD4 T-cells are activated or when monocytes are induced to differentiate into macrophages. This change correlates with increased susceptibility of these cells to HIV-1 infection.
Post Translational Modifications	Ubiquitinated in the presence of HIV-1 Vif. Association with Vif targets the protein for proteolysis by the ubiquitin-dependent proteasome pathway. Phosphorylation at Thr-32 reduces its binding to HIV-1 Vif and subsequent ubiquitination and degradation thus promoting its antiviral activity.
Function	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Protein Name	Dna Dc->Du-Editing Enzyme Apobec-3g Apobec-Related Cytidine Deaminase Apobec-Related Protein Arcd Apobec-Related Protein 9 Arp-9 Cem-15 Cem15 Deoxycytidine Deaminase A3g
Database Links	Reactome: R-HSA-180585 Reactome: R-HSA-180689
Cellular Localisation	Cytoplasm Nucleus P-Body Mainly Cytoplasmic Small Amount Are Found In The Nucleus During Hiv-1 Infection Virion-Encapsidated In Absence Of Hiv-1 Vif
Alternative Antibody Names	Anti-Dna Dc->Du-Editing Enzyme Apobec-3g antibody Anti-Apobec-Related Cytidine Deaminase antibody Anti-Apobec-Related Protein antibody Anti-Arcd antibody Anti-Apobec-Related Protein 9 antibody Anti-Arp-9 antibody Anti-Cem-15 antibody Anti-Cem15 antibody Anti-Deoxycytidine Deaminase antibody Anti-A3g antibody Anti-APOBEC3G antibody Anti-MDS019 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-APOBEC3G antibody (244-257) (STJ115559)