Human E2F1 (E2F Transcription Factor 1) Sandwich ELISA Kit Ready-To-Use (STJE0014924) STJE0014924 上海玉博生物科技有限公司

Human E2F1 (E2F Transcription Factor 1) Sandwich ELISA Kit Ready-To-Use (STJE0014924)

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产品名称：Human E2F1 (E2F Transcription Factor 1) Sandwich ELISA Kit Ready-To-Use (STJE0014924)
产品型号：STJE0014924
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human E2F1 (E2F Transcription Factor 1) Sandwich ELISA Kit Ready-To-Use (STJE0014924)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.054ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This E2F1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	E2F1
Gene ID:	1869
Uniprot ID:	E2F1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis. Phosphorylation at Ser-403 by GSK3B promotes interaction with USP11, leading to its deubiquitination and stabilization. Ubiquitinated via 'Lys-63'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP11 follwong phosphorylation by GSK3B, promoting its stability. Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B. Methylation at Lys-185 by SETD7 promotes E2F1 ubiquitin-dependent proteasomal degradation.
Function	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B.
Protein Name	Transcription Factor E2f1 E2f-1 Pbr3 Retinoblastoma-Associated Protein 1 Rbap-1 Retinoblastoma-Binding Protein 3 Rbbp-3 Prb-Binding Protein E2f-1
Database Links	Reactome: R-HSA-111448 Reactome: R-HSA-113501 Reactome: R-HSA-1362277 Reactome: R-HSA-1362300 Reactome: R-HSA-139915 Reactome: R-HSA-1912408 Reactome: R-HSA-2559580 Reactome: R-HSA-2559585 Reactome: R-HSA-6804116 Reactome: R-HSA-68911 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69656 Reactome: R-HSA-8953750 Reactome: R-HSA-9616222 Reactome: R-HSA-9661069
Cellular Localisation	Nucleus
Alternative ELISA Names	Transcription Factor E2f1 ELISA kit E2f-1 ELISA kit Pbr3 ELISA kit Retinoblastoma-Associated Protein 1 ELISA kit Rbap-1 ELISA kit Retinoblastoma-Binding Protein 3 ELISA kit Rbbp-3 ELISA kit Prb-Binding Protein E2f-1 ELISA kit E2F1 ELISA kit RBBP3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human E2F1 (E2F Transcription Factor 1) Sandwich ELISA Kit Ready-To-Use (STJE0014924)