Anti-BAP1 antibody (1-270) (STJ28616) STJ28616 上海玉博生物科技有限公司

Anti-BAP1 antibody (1-270) (STJ28616)

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产品名称：Anti-BAP1 antibody (1-270) (STJ28616)
产品型号：STJ28616
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BAP1 antibody (1-270) (STJ28616)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BAP1 (1-270) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BAP1
Gene ID:	8314
Uniprot ID:	BAP1_HUMAN
Immunogen Region:	1-270
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human BAP1 (NP_004647.1).
Immunogen Sequence:	MNKGWLELESDPGLFTLLVE DFGVKGVQVEEIYDLQSKCQ GPVYGFIFLFKWIEERRSRR KVSTLVDDTSVIDDDIVNNM FFAHQLIPNSCATHALLSVL LNCSSVDLGPTLSRMKDFTK GFSPESKGYAIGNAPELAKA HNSHARPEPRHLPEKQNGLS AVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDE EWTDKARRVIMERIGLATAG EPYHDIRFNLMAVVPDRRI

Tissue Specificity	Highly expressed in testis, placenta and ovary. Expressed in breast.
Post Translational Modifications	Ubiquitinated: monoubiquitinated at multiple site of its nuclear localization signal (NLS) BY UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to couteract cytoplasmic retention.
Function	Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.
Protein Name	Ubiquitin Carboxyl-Terminal Hydrolase Bap1 Brca1-Associated Protein 1 Cerebral Protein 6
Database Links	Reactome: R-HSA-5689603 Reactome: R-HSA-5693565
Cellular Localisation	Cytoplasm Nucleus Mainly Nuclear Binds To Chromatin Localizes To The Cytoplasm When Monoubiquitinated By The E2/E3 Hybrid Ubiquitin-Protein Ligase Ube2o
Alternative Antibody Names	Anti-Ubiquitin Carboxyl-Terminal Hydrolase Bap1 antibody Anti-Brca1-Associated Protein 1 antibody Anti-Cerebral Protein 6 antibody Anti-BAP1 antibody Anti-KIAA0272 antibody Anti-hucep-6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BAP1 antibody (1-270) (STJ28616)