Anti-BARD1 antibody (1-50 aa) (STJ91817) STJ91817 上海玉博生物科技有限公司

Anti-BARD1 antibody (1-50 aa) (STJ91817)

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产品名称：Anti-BARD1 antibody (1-50 aa) (STJ91817)
产品型号：STJ91817
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BARD1 antibody (1-50 aa) (STJ91817)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BRCA1-associated RING domain protein 1 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BARD1
Gene ID:	580
Uniprot ID:	BARD1_HUMAN
Immunogen Region:	1-50 aa
Specificity:	BARD1 Polyclonal Antibody detects endogenous levels of BARD1 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human BARD1 at the amino acid range 1-50

Function	E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Protein Name	Brca1-Associated Ring Domain Protein 1 Bard-1 Ring-Type E3 Ubiquitin Transferase Bard1
Database Links	Reactome: R-HSA-5685938 Reactome: R-HSA-5685942 Reactome: R-HSA-5689603 Reactome: R-HSA-5689901 Reactome: R-HSA-5693554 Reactome: R-HSA-5693565 Reactome: R-HSA-5693568 Reactome: R-HSA-5693571 Reactome: R-HSA-5693579 Reactome: R-HSA-5693607 Reactome: R-HSA-5693616 Reactome: R-HSA-6804756 Reactome: R-HSA-69473 Reactome: R-HSA-9663199 Reactome: R-HSA-9699150 Reactome: R-HSA-9701192 Reactome: R-HSA-9704331 Reactome: R-HSA-9704646 Reactome: R-HSA-9709570 Reactome: R-HSA-9709603
Cellular Localisation	Nucleus During S Phase Of The Cell Cycle Colocalizes With Brca1 Into Discrete Subnuclear Foci Can Translocate To The Cytoplasm Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) Recruitment To Dna Damage Sites Is Mediated By The Brca1-A Complex
Alternative Antibody Names	Anti-Brca1-Associated Ring Domain Protein 1 antibody Anti-Bard-1 antibody Anti-Ring-Type E3 Ubiquitin Transferase Bard1 antibody Anti-BARD1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BARD1 antibody (1-50 aa) (STJ91817)