Anti-BATF antibody (1-125) (STJ116871) STJ116871 上海玉博生物科技有限公司

Anti-BATF antibody (1-125) (STJ116871)

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产品名称：Anti-BATF antibody (1-125) (STJ116871)
产品型号：STJ116871
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BATF antibody (1-125) (STJ116871)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BATF (1-125) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BATF
Gene ID:	10538
Uniprot ID:	BATF_HUMAN
Immunogen Region:	1-125
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human BATF (NP_006390.1).
Immunogen Sequence:	MPHSSDSSDSSFSRSPPPGK QDSSDDVRRVQRREKNRIAA QKSRQRQTQKADTLHLESED LEKQNAALRKEIKQLTEELK YFTSVLNSHEPLCSVLAAST PSPPEVVYSAHAFHQPHVSS PRFQP

Tissue Specificity	Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow.
Post Translational Modifications	Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription. Phosphorylated.
Function	AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGACGTCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.
Protein Name	Basic Leucine Zipper Transcriptional Factor Atf-Like B-Cell-Activating Transcription Factor B-Atf Sf-Ht-Activated Gene 2 Protein Sfa-2
Database Links	Reactome: R-HSA-6785807
Cellular Localisation	Nucleus Cytoplasm Present In The Nucleus And Cytoplasm But Shows Increased Nuclear Translocation After Activation Of T-Cells
Alternative Antibody Names	Anti-Basic Leucine Zipper Transcriptional Factor Atf-Like antibody Anti-B-Cell-Activating Transcription Factor antibody Anti-B-Atf antibody Anti-Sf-Ht-Activated Gene 2 Protein antibody Anti-Sfa-2 antibody Anti-BATF antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BATF antibody (1-125) (STJ116871)