Human EFNA5 (Ephrin-A5) CLIA Kit (STJC0000536) STJC0000536 上海玉博生物科技有限公司

Human EFNA5 (Ephrin-A5) CLIA Kit (STJC0000536)

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产品名称：Human EFNA5 (Ephrin-A5) CLIA Kit (STJC0000536)
产品型号：STJC0000536
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human EFNA5 (Ephrin-A5) CLIA Kit (STJC0000536)

产品描述

Applications:	CLIA
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity:	18.75pg/mL
Detection Limit:	31.25~2000pg/mL
Short Description:	This human EFNA5 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.

Storage Instruction:	If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time:	3.5h
Detection:	Chemiluminescence

Gene Symbol:	EFNA5
Gene ID:	1946
Uniprot ID:	EFNA5_HUMAN
Specificity:	This kit recognizes Human EFNA5 in samples. No significant cross-reactivity or interference between Human EFNA5 and analogues was observed.
Sample Type:	Serum, plasma and other biological fluids

Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Protein Name	Ephrin-A5 Al-1 Eph-Related Receptor Tyrosine Kinase Ligand 7 Lerk-7
Database Links	Reactome: R-HSA-2682334 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Membrane Caveola Compartmentalized In Discrete Caveolae-Like Membrane Microdomains
Alternative CLIA Names	Ephrin-A5 CLIA kit Al-1 CLIA kit Eph-Related Receptor Tyrosine Kinase Ligand 7 CLIA kit Lerk-7 CLIA kit EFNA5 CLIA kit EPLG7 CLIA kit LERK7 CLIA kit
Specificity	This kit recognizes Human EFNA5 in samples. No significant cross-reactivity or interference between Human EFNA5 and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are

Information sourced from Uniprot.org

Item Specifications Storage

Micro CLIA Plate (Dismountable)	96T: 8 wells ×12 strips strips	-20℃, 6 months
Reference Standard	96T: 2 vials 48T: 1 vial	-20℃, 6 months
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 60 μL	-20℃, 6 months
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 60 μL	-20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 6 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL	2-8°C, 6 months
HRP Conjugate Diluent	1 vial, 14 mL	2-8°C, 6 months
Concentrated Wash Buffer (25×)	1 vial, 30 mL	2-8°C, 6 months
Substrate Reagent A	1 vial, 5 mL	2-8℃ (Protect from light)
Substrate Reagent B	1 vial, 5 mL	2-8℃ (Protect from light)
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Sample Type Range (%) Average Recovery (%)

Serum(n=8)	101-115	108
EDTA plasma(n=8)	88-100	95
Cell culture media(n=8)	86-96	91

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision

Sample	1.00	2.00	3.00	1.00	2.00	3.00
n	20.00	20.00	20.00	20.00	20.00	20.00
Mean (pg/mL)	104.75	308.40	967.24	94.66	332.85	951.96
Standard deviation	8.99	28.87	61.90	8.07	31.19	85.20
CV (%)	8.58	9.36	6.40	8.53	9.37	8.95

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human EFNA5 (Ephrin-A5) CLIA Kit (STJC0000536)