Anti-BAX antibody (1-211) (STJ29763) STJ29763 上海玉博生物科技有限公司

Anti-BAX antibody (1-211) (STJ29763)

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产品名称：Anti-BAX antibody (1-211) (STJ29763)
产品型号：STJ29763
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BAX antibody (1-211) (STJ29763)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Bax (1-211) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BAX
Gene ID:	581
Uniprot ID:	BAX_HUMAN
Immunogen Region:	1-211
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human Bax (NP_001179.1).
Immunogen Sequence:	MASGQGPGPPRQECGEPALP SASEEQVAQDTEEVFRSYVF YRHQQEQEAEGVAAPADPEM VTLPLQPSSTMGQVGRQLAI IGDDINRRYDSEFQTMLQHL

Tissue Specificity	Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Post Translational Modifications	Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12.
Function	Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Protein Name	Apoptosis Regulator Bax Bcl-2-Like Protein 4 Bcl2-L-4
Database Links	Reactome: R-HSA-111457 Reactome: R-HSA-114294 Reactome: R-HSA-5620971 Reactome: R-HSA-6803204 Reactome: R-HSA-6804114 Reactome: R-HSA-8878166 Reactome: R-HSA-9603505
Cellular Localisation	Isoform Alpha: Mitochondrion Outer Membrane Single-Pass Membrane Protein Cytoplasm Nucleus Colocalizes With 14-3-3 Proteins In The Cytoplasm Under Stress Conditions Undergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion Membrane Upon Sendai Virus Infection Recruited To The Mitochondrion Through Interaction With Irf3 Isoform Beta: Cytoplasm Isoform Gamma: Cytoplasm Isoform Delta: Cytoplasm
Alternative Antibody Names	Anti-Apoptosis Regulator Bax antibody Anti-Bcl-2-Like Protein 4 antibody Anti-Bcl2-L-4 antibody Anti-BAX antibody Anti-BCL2L4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BAX antibody (1-211) (STJ29763)