Anti-BAX antibody (90aa N-Term) (STJ140113) STJ140113 上海玉博生物科技有限公司

Anti-BAX antibody (90aa N-Term) (STJ140113)

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产品名称：Anti-BAX antibody (90aa N-Term) (STJ140113)
产品型号：STJ140113
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BAX antibody (90aa N-Term) (STJ140113)

产品描述

Host:	Goat
Applications:	WB/IHC-F/IHC-P/IF
Reactivity:	Human/Rat/Mouse/Monkey/Canine
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BCL2-associated X protein (90aa N-Term) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS, 20% Glycerol and 0.05% Sodium Azide.
Purification:	This antibody is epitope-affinity purified from goat antiserum.
Concentration:	2 mg/ml
Dilution Range:	WB 1:500-1:5000 IF 1:50-1:250 IHC-F 1:250-1:1000 IHC-P 1:250-1:1000 Yu X He W Xie J et al. J Cardiovasc Electrophysiol. 2018 Dec. PMID: 30516302
Storage Instruction:	For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Gene Symbol:	BAX
Gene ID:	581
Uniprot ID:	BAX_HUMAN
Immunogen Region:	90aa N-Term
Accession Number:	ENSG
Specificity:	Detects a band of approximately 21 kDa by Western blot in the following cell lysate: hCat, At-T20, MDA-MB-231, H69 and HUH.
Immunogen:	Purified recombinant peptide derived from within residues 90 aa to the N-terminus of human BAX produced in E. coli.

Tissue Specificity	Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Post Translational Modifications	Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12.
Function	Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Protein Name	Apoptosis Regulator Bax Bcl-2-Like Protein 4 Bcl2-L-4
Database Links	Reactome: R-HSA-111457 Reactome: R-HSA-114294 Reactome: R-HSA-5620971 Reactome: R-HSA-6803204 Reactome: R-HSA-6804114 Reactome: R-HSA-8878166 Reactome: R-HSA-9603505
Cellular Localisation	Isoform Alpha: Mitochondrion Outer Membrane Single-Pass Membrane Protein Cytoplasm Nucleus Colocalizes With 14-3-3 Proteins In The Cytoplasm Under Stress Conditions Undergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion Membrane Upon Sendai Virus Infection Recruited To The Mitochondrion Through Interaction With Irf3 Isoform Beta: Cytoplasm Isoform Gamma: Cytoplasm Isoform Delta: Cytoplasm
Alternative Antibody Names	Anti-Apoptosis Regulator Bax antibody Anti-Bcl-2-Like Protein 4 antibody Anti-Bcl2-L-4 antibody Anti-BAX antibody Anti-BCL2L4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BAX antibody (90aa N-Term) (STJ140113)