Anti-APPBP2 antibody (386-585) (STJ118226) STJ118226 上海玉博生物科技有限公司

Anti-APPBP2 antibody (386-585) (STJ118226)

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产品名称：Anti-APPBP2 antibody (386-585) (STJ118226)
产品型号：STJ118226
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-APPBP2 antibody (386-585) (STJ118226)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-APPBP2 (386-585) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	APPBP2
Gene ID:	10513
Uniprot ID:	APBP2_HUMAN
Immunogen Region:	386-585
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 386-585 of human APPBP2 (NP_006371.2).
Immunogen Sequence:	LEEIAIDCHNKETEQRLLQE AHDLHLSSLQLAKKAFGEFN VQTAKHYGNLGRLYQSMRKF KEAEEMHIKAIQIKEQLLGQ EDYEVALSVGHLASLYNYDM NQYENAEKLYLRSIAIGKKL FGEGYSGLEYDYRGLIKLYN SIGNYEKVFEYHNVLSNWNR LRDRQYSVTDALEDVSTSPQ STEEVVQSFLISQNVEGPSC

Post Translational Modifications	Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
Function	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.
Protein Name	Amyloid Protein-Binding Protein 2 Amyloid Beta Precursor Protein-Binding Protein 2 App-Bp2 Protein Interacting With App Tail 1
Cellular Localisation	Nucleus Cytoplasm Cytoskeleton Membrane Peripheral Membrane Protein Associated With Membranes And Microtubules
Alternative Antibody Names	Anti-Amyloid Protein-Binding Protein 2 antibody Anti-Amyloid Beta Precursor Protein-Binding Protein 2 antibody Anti-App-Bp2 antibody Anti-Protein Interacting With App Tail 1 antibody Anti-APPBP2 antibody Anti-KIAA0228 antibody Anti-PAT1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-APPBP2 antibody (386-585) (STJ118226)