Anti-APPL/DIP13alpha antibody (C-Term) (STJ70418) STJ70418-100 上海玉博生物科技有限公司

Anti-APPL/DIP13alpha antibody (C-Term) (STJ70418)

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产品名称：Anti-APPL/DIP13alpha antibody (C-Term) (STJ70418)
产品型号：STJ70418-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-APPL/DIP13alpha antibody (C-Term) (STJ70418)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-APPL/DIP13alpha (C-Term) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.3-1µg/ml ELISA-antibody detection limit dilution 1:2000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	APPL1
Gene ID:	26060
Uniprot ID:	DP13A_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_036228.1
Immunogen Sequence:	DLGEGGKKRESEA

Post Translational Modifications	Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.
Function	Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages. Regulates TLR4 signaling in activated macrophages. Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways. Required for fibroblast migration through HGF cell signaling. Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex.
Protein Name	Dcc-Interacting Protein 13-Alpha Dip13-Alpha Adapter Protein Containing Ph Domain - Ptb Domain And Leucine Zipper Motif 1
Database Links	Reactome: R-HSA-418889
Cellular Localisation	Early Endosome Membrane Peripheral Membrane Protein Nucleus Cytoplasm Endosome Cell Projection Ruffle Cytoplasmic Vesicle Phagosome Early Endosomal Membrane-Bound And Nuclear Translocated Into The Nucleus Upon Release From Endosomal Membranes Following Internalization Of Egf
Alternative Antibody Names	Anti-Dcc-Interacting Protein 13-Alpha antibody Anti-Dip13-Alpha antibody Anti-Adapter Protein Containing Ph Domain - Ptb Domain And Leucine Zipper Motif 1 antibody Anti-APPL1 antibody Anti-APPL antibody Anti-DIP13A antibody Anti-KIAA1428 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-APPL/DIP13alpha antibody (C-Term) (STJ70418)