Anti-APTX antibody (11-60 aa) (STJ192599) STJ192599 上海玉博生物科技有限公司

Anti-APTX antibody (11-60 aa) (STJ192599)

简单介绍

Anti-APTX antibody (11-60 aa) (STJ192599)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Aprataxin (11-60 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	APTX
Gene ID:	54840
Uniprot ID:	APTX_HUMAN
Immunogen Region:	11-60 aa
Specificity:	APTX Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from the human protein at the amino acid range 11-60

Function	DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Protein Name	Aprataxin Forkhead-Associated Domain Histidine Triad-Like Protein Fha-Hit
Cellular Localisation	Nucleus Nucleoplasm Nucleolus Upon Genotoxic Stress Colocalizes With Xrcc1 At Sites Of Dna Damage Colocalizes With Mdc1 At Sites Of Dna Double-Strand Breaks Interaction With Ncl Is Required For Nucleolar Localization Isoform 12: Cytoplasm
Alternative Antibody Names	Anti-Aprataxin antibody Anti-Forkhead-Associated Domain Histidine Triad-Like Protein antibody Anti-Fha-Hit antibody Anti-APTX antibody Anti-AXA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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