Human ELAVL1 (ELAV Like Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015002) STJE0015002 上海玉博生物科技有限公司

Human ELAVL1 (ELAV Like Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015002)

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产品名称：Human ELAVL1 (ELAV Like Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015002)
产品型号：STJE0015002
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human ELAVL1 (ELAV Like Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015002)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.118ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This ELAVL1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	ELAVL1
Gene ID:	1994
Uniprot ID:	ELAV1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Ubiquitous. Detected in brain, liver, thymus and muscle.
Post Translational Modifications	Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD. Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
Function	RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation. Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUUAGUUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR.
Protein Name	Elav-Like Protein 1 Hu-Antigen R Hur
Database Links	Reactome: R-HSA-450520
Cellular Localisation	Cytoplasm Nucleus Stress Granule P-Body Translocates Into The Cytoplasm Following Phosphorylation By Mapkapk2 Likewise Phosphorylation By Prkcd Promotes Translocation From The Nucleus Into The Cytoplasm Where It Is Associated With Free And Cytoskeleton-Bound Polysomes Localizes To The Stress Granules In The Presence Of Plekhn1
Alternative ELISA Names	Elav-Like Protein 1 ELISA kit Hu-Antigen R ELISA kit Hur ELISA kit ELAVL1 ELISA kit HUR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human ELAVL1 (ELAV Like Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015002)