Human ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Sandwich ELISA Kit (STJE0008650) STJE0008650 上海玉博生物科技有限公司

Human ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Sandwich ELISA Kit (STJE0008650)

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产品名称：Human ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Sandwich ELISA Kit (STJE0008650)
产品型号：STJE0008650
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Sandwich ELISA Kit (STJE0008650)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	32.28pg/mL
Detection Limit:	93.7-6000pg/mL
Short Description:	This ENPP2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	ENPP2
Gene ID:	5168
Uniprot ID:	ENPP2_HUMAN
Sample Type:	serum, plasma or other biological fluids.

Tissue Specificity	Detected in blood plasma (at protein level). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.
Post Translational Modifications	N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. The interdomain disulfide bond between Cys-414 and Cys-806 is essential for catalytic activity.
Function	Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Protein Name	Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 E-Npp 2 Autotaxin Extracellular Lysophospholipase D Lysopld
Database Links	Reactome: R-HSA-199220
Cellular Localisation	Secreted
Alternative ELISA Names	Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 ELISA kit E-Npp 2 ELISA kit Autotaxin ELISA kit Extracellular Lysophospholipase D ELISA kit Lysopld ELISA kit ENPP2 ELISA kit ATX ELISA kit PDNP2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Sandwich ELISA Kit (STJE0008650)