Anti-BCKDHA antibody (276-445) (STJ11104430) STJ11104430 上海玉博生物科技有限公司

Anti-BCKDHA antibody (276-445) (STJ11104430)

简单介绍

Anti-BCKDHA antibody (276-445) (STJ11104430)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-2-Oxoisovalerate Dehydrogenase Subunit Alpha-Mitochondrial (276-445) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BCKDHA
Gene ID:	593
Uniprot ID:	ODBA_HUMAN
Immunogen Region:	276-445
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 276-445 of human BCKDHA (NP_000700.1).
Immunogen Sequence:	SEQYRGDGIAARGPGYGIMS IRVDGNDVFAVYNATKEARR RAVAENQPFLIEAMTYRIGH HSTSDDSSAYRSVDEVNYWD KQDHPISRLRHYLLSQGWWD EEQEKAWRKQSRRKVMEAFE QAERKPKPNPNLLFSDVYQE MPAQLRKQQESLARHLQTYG EHYPLDHFDK

Function	Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.
Protein Name	2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain Bckde1a Bckdh E1-Alpha
Database Links	Reactome: R-HSA-389661 Reactome: R-HSA-70895
Cellular Localisation	Mitochondrion Matrix
Alternative Antibody Names	Anti-2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial antibody Anti-Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain antibody Anti-Bckde1a antibody Anti-Bckdh E1-Alpha antibody Anti-BCKDHA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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