Human GDNFR-alpha-2/GFRA2 protein (Recombinant) (C-His) (STJP000972) STJP000972 上海玉博生物科技有限公司

Human GDNFR-alpha-2/GFRA2 protein (Recombinant) (C-His) (STJP000972)

简单介绍

Human GDNFR-alpha-2/GFRA2 protein (Recombinant) (C-His) (STJP000972)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human GDNFR-alpha-2/GFRA2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized recombinant Human Neurturin at 5 Mu g/mL (100 Mu L/well) can bind recombinant Human GFRA2, the EC50 of Human GFRA2 is 1.82 Mu g/mL.

Gene Symbol:	GFRA2
Gene ID:	2675
Uniprot ID:	GFRA2_HUMAN
Immunogen:	Recombinant Human GDNFR-alpha-2/GFRA2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ser22-Ser441) of human GFRA2/GFR Alpha 2/GDNFRB (Accession #NP_001486.4) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Isoform 1 is found in both brain and placenta.
Function	Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Protein Name	Gdnf Family Receptor Alpha-2 Gdnf Receptor Alpha-2 Gdnfr-Alpha-2 Gfr-Alpha-2 Gdnf Receptor Beta Gdnfr-Beta Neurturin Receptor Alpha Nrtnr-Alpha Ntnr-Alpha Ret Ligand 2 Tgf-Beta-Related Neurotrophic Factor Receptor 2
Database Links	Reactome: R-HSA-419037 Reactome: R-HSA-5673001 Reactome: R-HSA-8853659
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor
Alternative Protein Names	Gdnf Family Receptor Alpha-2 protein Gdnf Receptor Alpha-2 protein Gdnfr-Alpha-2 protein Gfr-Alpha-2 protein Gdnf Receptor Beta protein Gdnfr-Beta protein Neurturin Receptor Alpha protein Nrtnr-Alpha protein Ntnr-Alpha protein Ret Ligand 2 protein Tgf-Beta-Related Neurotrophic Factor Receptor 2 protein GFRA2 protein GDNFRB protein RETL2 protein TRNR2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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