Anti-ADAMTS5 antibody (601-700) [S5023RM] (STJ11105023) STJ11105023 上海玉博生物科技有限公司

Anti-ADAMTS5 antibody (601-700) [S5023RM] (STJ11105023)

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产品名称：Anti-ADAMTS5 antibody (601-700) [S5023RM] (STJ11105023)
产品型号：STJ11105023
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ADAMTS5 antibody (601-700) [S5023RM] (STJ11105023)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 (601-700) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S5023RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ADAMTS5
Gene ID:	11096
Uniprot ID:	ATS5_HUMAN
Immunogen Region:	601-700
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 601-700 of human ADAMTS5 (NP_008969.2).
Immunogen Sequence:	NNGRYCTGKRAIYRSCSLMP CPPNGKSFRHEQCEAKNGYQ SDAKGVKTFVEWVPKYAGVL PADVCKLTCRAKGTGYYVVF SPKVTDGTECRLYSNSVCVR

Tissue Specificity	Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
Post Translational Modifications	The precursor is cleaved by furin and PCSK7 outside of the cell. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function	Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Protein Name	A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Adam-Ts 5 Adam-Ts5 Adamts-5 A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11 Adam-Ts 11 Adamts-11 Admp-2 Aggrecanase-2
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-5083635 Reactome: R-HSA-5173214
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 antibody Anti-Adam-Ts 5 antibody Anti-Adam-Ts5 antibody Anti-Adamts-5 antibody Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11 antibody Anti-Adam-Ts 11 antibody Anti-Adamts-11 antibody Anti-Admp-2 antibody Anti-Aggrecanase-2 antibody Anti-ADAMTS5 antibody Anti-ADAMTS11 antibody Anti-ADMP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ADAMTS5 antibody (601-700) [S5023RM] (STJ11105023)