Anti-ADRA1A antibody (150-250) [S5756RM] (STJ11105756) STJ11105756 上海玉博生物科技有限公司

Anti-ADRA1A antibody (150-250) [S5756RM] (STJ11105756)

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产品名称：Anti-ADRA1A antibody (150-250) [S5756RM] (STJ11105756)
产品型号：STJ11105756
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ADRA1A antibody (150-250) [S5756RM] (STJ11105756)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Alpha-1a Adrenergic Receptor (150-250) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S5756RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ADRA1A
Gene ID:	148
Uniprot ID:	ADA1A_HUMAN
Immunogen Region:	150-250
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ADRA1A (P35348).
Immunogen Sequence:	VWALSLVISIGPLFGWRQPA PEDETICQINEEPGYVLFSA LGSFYLPLAIILVMYCRVYV VAKRESRGLKSGLKTDKSDS EQVTLRIHRKNAPAGGSGMA S

Tissue Specificity	Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Post Translational Modifications	C-terminal Ser or Thr residues may be phosphorylated.
Function	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Protein Name	Alpha-1a Adrenergic Receptor Alpha-1a Adrenoreceptor Alpha-1a Adrenoceptor Alpha-1c Adrenergic Receptor Alpha-Adrenergic Receptor 1c
Database Links	Reactome: R-HSA-390696 Reactome: R-HSA-416476 Reactome: R-HSA-416482
Cellular Localisation	Nucleus Membrane Multi-Pass Membrane Protein Cell Membrane Cytoplasm Membrane Caveola Location At The Nuclear Membrane Facilitates Heterooligomerization And Regulates Erk-Mediated Signaling In Cardiac Myocytes Colocalizes With Gnaq Plcb1 As Well As Lap2 At The Nuclear Membrane Of Cardiac Myocytes
Alternative Antibody Names	Anti-Alpha-1a Adrenergic Receptor antibody Anti-Alpha-1a Adrenoreceptor antibody Anti-Alpha-1a Adrenoceptor antibody Anti-Alpha-1c Adrenergic Receptor antibody Anti-Alpha-Adrenergic Receptor 1c antibody Anti-ADRA1A antibody Anti-ADRA1C antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ADRA1A antibody (150-250) [S5756RM] (STJ11105756)