Anti-AIFM1 antibody [8H1-B10-A12] (STJ99301) STJ99301 上海玉博生物科技有限公司

Anti-AIFM1 antibody [8H1-B10-A12] (STJ99301)

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产品名称：Anti-AIFM1 antibody [8H1-B10-A12] (STJ99301)
产品型号：STJ99301
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-AIFM1 antibody [8H1-B10-A12] (STJ99301)

产品描述

Host:	Mouse
Applications:	WB/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Apoptosis-inducing factor 1, mitochondrial is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	8H1-B10-A12
Conjugation:	Unconjugated
Isotype:	IgG2a
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000 ICC 1:200 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	AIFM1
Gene ID:	9131
Uniprot ID:	AIFM1_HUMAN
Specificity:	This antibody detects endogenous levels of AIF and does not cross-react with related proteins.
Immunogen:	Purified recombinant human AIF protein fragments expressed in E.coli.

Post Translational Modifications	Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner. Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. Ubiquitination at Lys-255 by XIAP/BIRC4 blocks its ability to bind DNA and induce chromatin degradation, thereby inhibiting its ability to induce cell death.
Function	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import. Isoform 4: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. Isoform 5: Pro-apoptotic isoform.
Protein Name	Apoptosis-Inducing Factor 1 - Mitochondrial Programmed Cell Death Protein 8
Cellular Localisation	Mitochondrion Intermembrane Space Mitochondrion Inner Membrane Cytoplasm Nucleus Perinuclear Region Proteolytic Cleavage During Or Just After Translocation Into The Mitochondrial Intermembrane Space (Ims) Results In The Formation Of An Inner-Membrane-Anchored Mature Form (Aifmit) During Apoptosis Further Proteolytic Processing Leads To A Mature Form Which Is Confined To The Mitochondrial Ims In A Soluble Form (Aifsol) Aifsol Is Released To The Cytoplasm In Response To Specific Death Signals And Translocated To The Nucleus Where It Induces Nuclear Apoptosis Release Into The Cytoplasm Is Mediated Upon Binding To Poly-Adp-Ribose Chains Translocation Into The Nucleus Is Promoted By Interaction With (Auto-Poly-Adp-Ribosylated) Processed Form Of Parp1 Colocalizes With Eif3g In The Nucleus And Perinuclear Region Isoform 3: Mitochondrion Intermembrane Space Has A Stronger Membrane Anchorage Than Isoform 1 Isoform 4: Mitochondrion Cytosol In Pro-Apoptotic Conditions Is Released From Mitochondria To Cytosol In A Calpain/Cathepsin-Dependent Manner Isoform 5: Cytoplasm
Alternative Antibody Names	Anti-Apoptosis-Inducing Factor 1 - Mitochondrial antibody Anti-Programmed Cell Death Protein 8 antibody Anti-AIFM1 antibody Anti-AIF antibody Anti-PDCD8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-AIFM1 antibody [8H1-B10-A12] (STJ99301)