Human Stem Cell Factor protein (Recombinant) {Biotin} (STJP000205) STJP000205 上海玉博生物科技有限公司

Human Stem Cell Factor protein (Recombinant) {Biotin} (STJP000205)

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产品名称：Human Stem Cell Factor protein (Recombinant) {Biotin} (STJP000205)
产品型号：STJP000205
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human Stem Cell Factor protein (Recombinant) {Biotin} (STJP000205)

产品描述

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Stem Cell Factor-protein was developed from hek293. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised from 0.2 Mu m filtered solution in PBS pH7.0.
Dilution Range:	Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction:	Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity:	Activity was tested by the ability to bind Human SCF receptor in a functional ELISA assay with a linear range of 0.1-5.0 ng/ml. NA

Gene Symbol:	KITLG
Gene ID:	4254
Uniprot ID:	SCF_HUMAN
Immunogen Region:	Mature chain
Immunogen:	Optimized DNA sequence encoding Human SCF mature chain fused to PolyHis AVI tag was expressed in HEK293 Cells, was further labeled by Biotin for detection by Avidin conjugated secondary probes. NA

Post Translational Modifications	A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain. Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97. A soluble form exists as a cleavage product of the extracellular domain.
Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name	Kit Ligand Mast Cell Growth Factor Mgf Stem Cell Factor Scf C-Kit Ligand Cleaved Into - Soluble Kit Ligand Skitlg
Database Links	Reactome: R-HSA-1257604 P21583-1 Reactome: R-HSA-1433557 P21583-1 Reactome: R-HSA-1433559 P21583-1 Reactome: R-HSA-2219530 P21583-1 Reactome: R-HSA-5673001 P21583-1 Reactome: R-HSA-6811558 P21583-1
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cytoplasm Cytoplasm Cytoskeleton Cell Membrane Cell Projection Lamellipodium Filopodium Soluble Kit Ligand: Secreted
Alternative Protein Names	Kit Ligand protein Mast Cell Growth Factor protein Mgf protein Stem Cell Factor protein Scf protein C-Kit Ligand Cleaved Into - Soluble Kit Ligand protein Skitlg protein KITLG protein MGF protein SCF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human Stem Cell Factor protein (Recombinant) {Biotin} (STJP000205)