PDE2A1 Blocking Peptide peptide (STJ505338) STJ505338-250 上海玉博生物科技有限公司

PDE2A1 Blocking Peptide peptide (STJ505338)

简单介绍

PDE2A1 Blocking Peptide peptide (STJ505338)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	PDE2A1 Blocking Peptide is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PDE2A
Gene ID:	5138
Uniprot ID:	PDE2A_HUMAN
Immunogen Region:	1-50 aa
Immunogen:	Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A1 protein.

Tissue Specificity	Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Function	cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Peptide Name	Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase Cyclic Gmp-Stimulated Phosphodiesterase Cgs-Pde Cgspde
Database Links	Reactome: R-HSA-418457 Reactome: R-HSA-418555
Cellular Localisation	Isoform Pde2a3: Cell Membrane Lipid-Anchor Isoform Pde2a2: Mitochondrion Matrix Mitochondrion Inner Membrane Mitochondrion Outer Membrane Isoform Pde2a1: Cytoplasm Isoform 5: Mitochondrion
Alternative Peptide Names	Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase protein Cyclic Gmp-Stimulated Phosphodiesterase protein Cgs-Pde protein Cgspde protein PDE2A protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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