PKC eta Positive Control peptide (Phospho) (STJ504791) STJ504791-5 上海玉博生物科技有限公司

PKC eta Positive Control peptide (Phospho) (STJ504791)

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产品名称：PKC eta Positive Control peptide (Phospho) (STJ504791)
产品型号：STJ504791-5
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

PKC eta Positive Control peptide (Phospho) (STJ504791)

产品描述

Applications:	WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Phospho-PKC eta Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.

Dilution Range:	WB: 1:500
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PRKCH
Gene ID:	5583
Uniprot ID:	KPCL_HUMAN

Tissue Specificity	Most abundant in lung, less in heart and skin.
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.
Peptide Name	Protein Kinase C Eta Type Pkc-L Npkc-Eta
Database Links	Reactome: R-HSA-114508 Reactome: R-HSA-418597
Cellular Localisation	Cytoplasm
Alternative Peptide Names	Protein Kinase C Eta Type protein Pkc-L protein Npkc-Eta protein PRKCH protein PKCL protein PRKCL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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PKC eta Positive Control peptide (Phospho) (STJ504791)