Anti-AR antibody (1-100) (STJ114876) STJ114876 上海玉博生物科技有限公司

Anti-AR antibody (1-100) (STJ114876)

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产品名称：Anti-AR antibody (1-100) (STJ114876)
产品型号：STJ114876
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-AR antibody (1-100) (STJ114876)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Androgen Receptor (1-100) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	AR
Gene ID:	367
Uniprot ID:	ANDR_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Androgen Receptor (NP_000035.2).
Immunogen Sequence:	MEVQLGLGRVYPRPPSKTYR GAFQNLFQSVREVIQNPGPR HPEAASAAPPGASLLLLQQQ QQQQQQQQQQQQQQQQQQQQ ETSPRQQQQQQGEDGSPQAH

Tissue Specificity	Isoform 2: Mainly expressed in heart and skeletal muscle. Isoform 3: Expressed in basal and stromal cells of the prostate (at protein level).
Post Translational Modifications	Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity. Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-535 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-83 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition. Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.
Function	Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. Isoform 4: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
Protein Name	Androgen Receptor Dihydrotestosterone Receptor Nuclear Receptor Subfamily 3 Group C Member 4
Database Links	Reactome: R-HSA-3371497 Reactome: R-HSA-383280 Reactome: R-HSA-4090294 Reactome: R-HSA-5625886 Reactome: R-HSA-5689880 Reactome: R-HSA-8940973
Cellular Localisation	Nucleus Cytoplasm Detected At The Promoter Of Target Genes Predominantly Cytoplasmic In Unligated Form But Translocates To The Nucleus Upon Ligand-Binding Can Also Translocate To The Nucleus In Unligated Form In The Presence Of Rack1
Alternative Antibody Names	Anti-Androgen Receptor antibody Anti-Dihydrotestosterone Receptor antibody Anti-Nuclear Receptor Subfamily 3 Group C Member 4 antibody Anti-AR antibody Anti-DHTR antibody Anti-NR3C4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-AR antibody (1-100) (STJ114876)